15-deoxy-Δ12,14-prostaglandin J2 Down-Regulates Activin-Induced Activin Receptor, Smad, and Cytokines Expression via Suppression of NF-κB and MAPK Signaling in HepG2 Cells
Figure 3
IL-6 and IL-8 production in HepG2 cells. Cells were stimulated with activin A (25 ng/mL) and 15d-PGJ2 (2 or 5 μM) for 72 h. The amounts of IL-6 (a) and IL-8 (b) in the cell culture supernatants were determined using ELISA. The data represent the mean ± SEM of 3 independent samples. *, comparison of stimulation with 15d-PGJ2 and activin A versus activin A stimulation alone.
