PPARG in Human Adipogenesis: Differential Contribution of Canonical Transcripts and Dominant Negative Isoforms

Figure 1

Schematic representation of human PPARG gene, transcripts, and protein isoforms. In the upper part the genomic localization of PPARG gene is indicated, with chromosome indication, cytogenetic band, and surrounding genes. Below is depicted the exon/intron structure of PPARG gene with transcribed splicing variants. Transcripts encoding both the canonical and dominant negative proteins are illustrated in the left panel. The right panel shows a schematic representation of the encoded proteins with the functional domains.