Effects and Potential Mechanisms of Pioglitazone on Lipid Metabolism in Obese Diabetic KKAy Mice

Figure 1

Pioglitazone ameliorated systemic insulin resistance in diabetic KKAy mice. Fasting plasma glucose (a), insulin (b), and adiponectin (c) were measured at the end of the treatment. HOMA-IR (d) was calculated by (FPG (mg/dL) × FINS (ng/mL))/22.5. OGTT (e) and ITT (f) were performed in fasted animals on days 21 and 25 of treatment, respectively, as described in Section 2. Nor, C57BL/6J mice; Con, vehicle-treated KKAy mice; Piog, pioglitazone-treated KKAy mice. Data are presented as mean ± S.E.M. (𝑛=10 per group). *𝑃<0.05, **𝑃<0.01 versus Con.