Research Article
Effects and Potential Mechanisms of Pioglitazone on Lipid Metabolism in Obese Diabetic KKAy Mice
Table 1
Effects of pioglitazone on the expression of fatty acid metabolism related genes in the liver of KKAy mice.
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
The mRNA expression was examined by using the real-time PCR. Results are expressed as fold change, after correction for β-actin levels, relative to the control mice. Nor: C57BL/6J mice; Con: vehicle-treated KKAy mice; Piog: pioglitazone-treated KKAy mice. Data are presented as mean ± S.E.M. ( = 6–8 per group). , versus Con. SREBP-1: sterol regulatory element binding transcription factor 1; FASN: fatty acid synthase; SCD1: stearoyl-coenzyme A desaturase 1; DGAT-2: diacylglycerol O-acyltransferase 2; ACC: acetyl-coenzyme A carboxylase; ACOX-1: acyl-coenzyme A oxidase 1; CPT-1a: carnitine-palmitoyltransferase1a; FATP-1: long-chain fatty acid transport protein 1; mCAD: middle-chain acyl-CoA dehydrogenase; ApoB: apolipoprotein B; ApoC2: apolipoprotein C-II; ApoC3: apolipoprotein C-III; MTTP: microsomal triglyceride transfer protein; ATGL: adipose triglyceride lipase; HSL: hormone sensitive lipase; PPARα: peroxisome proliferator activated receptor alpha; PPARβ/δ: peroxisome proliferator activated receptor delta. |