Research Article
Effects and Potential Mechanisms of Pioglitazone on Lipid Metabolism in Obese Diabetic KKAy Mice
Table 2
Effects of pioglitazone on the expression of cholesterol metabolism related genes in the liver of KKAy mice.
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The mRNA expression was examined by using the real-time PCR. Results are expressed as fold change, after correction for β-actin levels, relative to the control mice. Nor: C57BL/6J mice; Con: vehicle-treated KKAy mice; Piog: pioglitazone-treated KKAy mice. Data are presented as mean ± S.E.M. ( = 6–8 per group). , versus Con. SREBP-2: sterol regulatory element binding transcription factor 1; HMGCR: 3-hydroxy-3-methylglutaryl-coenzyme A reductase; ApoA1: apolipoprotein A-I; ApoE: apolipoprotein E; SR-BI: scavenger receptor class B, member 1; LDLR: low density lipoprotein receptor; HL: hepatic lipase; ABCA1: ATP-binding cassette, subfamily A, member 1; ABCG5: ATP-binding cassette, subfamily G, member 5; ABCG8: ATP-binding cassette, subfamily G, member 8; Cyp7a1: cytochrome P450, family 7, subfamily a, polypeptide 1; Cyp27a1: cytochrome P450, family 27, subfamily a, polypeptide 1; ABCB11: ATP-binding cassette, subfamily B (MDR/TAP), member 11; ABCB4: ATP-binding cassette, subfamily B (MDR/TAP), member 4; NPC1-L1: Niemann-Pick C1 Like 1; ACAT-2: acetyl-coenzyme A acetyltransferase 2; LXRα: liver X receptor alpha; LXRβ: liver X receptor beta; FXR: farnesoid X receptor. |