The Pro12Ala Polymorphism of PPAR-γ Gene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han Population

Table 3

Distributions of genotype and allele frequencies in the sepsis subtypes and healthy controls.

Genotype	Healthy controls; 𝑛 (%)	Sepsis (subtype); 𝑛 (%)	Septic shock; 𝑛 (%)	Severe sepsis; 𝑛 (%)	𝑃 value			𝑃 value*
					𝑃1	𝑃2	𝑃3	𝑃1^∗	𝑃2^∗	𝑃3^∗
Total	345	30	97	181	0.012	0.264	0.327	0.042	0.336	0.336
Pro12Pro	318 (92.17)	23 (76.67)	93 (95.88)	171 (94.48)
Pro12Ala	27 (7.83)	7 (23.33)	4 (4.12)	10 (5.52)
Allele
Pro	663 (96.09)	53 (88.33)	190 (97.94)	352 (97.24)	0.014	0.273	0.336	0.042	0.336	0.336
Ala	27 (3.91)	7 (11.67)	4 (2.06)	10 (2.76)

OR: odds ratio; 95% CI: 95% confidence interval. ∗False discovery rate adjusted  𝑃 value for multiple hypothesis testing using the Benjamini-Hochberg method. 𝑃1 and 𝑃1^∗: healthy control group versus sepsis group. 𝑃2 and 𝑃2^∗: healthy control group versus septic shock group. 𝑃3 and 𝑃3^∗: healthy control group versus severe sepsis group. Fisher’s exact test: 𝑃1=0.012, OR = 3.585, and 95% CI (1.410–9.111) for genotype and 𝑃1=0.014, OR = 3.243, 95% CI (1.349–7.796) for allele.