Correlation of Circulating Acid-Labile Subunit Levels with Insulin Sensitivity and Serum LDL Cholesterol in Patients with Type 2 Diabetes: Findings from a Prospective Study with Rosiglitazone

Table 4

The correlations between HOMA2-%S and serum LDLc with ALS concentrations, analyzed with 4 linear regression models. Baseline serum ALS concentrations and change of ALS at 24 weeks were the dependent variables.

	Baseline ALS				Change of ALS at 24 weeks
	HOMA2-%S	𝑃	LDLc	𝑃	Change in; HOMA2-%S	𝑃	Change in; LDLc	𝑃
Unadjusted	−0.262±0.114	0.025	−0.156±0.068	0.025	3.923±2.711	0.156	−6.836±77.616	0.930
Model 1: age, sex, and BMI	−0.165±0.115	0.156	−0.165±0.062	0.010	4.122±2.832	0.154	−29.159±80.044	0.718
Model 2: age, sex, BMI, and HbA1c	−0.166±0.116	0.158	−0.171±0.063	0.009	5.421±2.789	0.060	−2.478±80.444	0.976
Model 3: age, sex, BMI, HbA1c, and LDLc	−0.145±0.111	0.196			5.819±2.844	0.048
Model 4: age, sex, BMI, HbA1c, and HOMA2-%S			−0.166±0.064	0.012			−11.370±80.531	0.889

Baseline levels of ALS and HOMA2-%S were log-transformed. ALS: acid-labile subunit; HbA1c: hemoglobin A1c; BMI: body mass index; HOMA2-%S: homeostatic model assessment version 2 insulin sensitivity; LDLc: low-density lipoprotein cholesterol.