Natural ligands | Unsaturated FA, PG, and LT B4 8-Hydroxyeicosatetraenoic acid | Unsaturated FA Carbaprostacyclin Components of VLDL | Unsaturated FA 15-Hydroxyeicosatetraenoic acid 9- and 13-hydroxyoctadecadienoic acid 15-Hydroxy delta 12,14-PG J2 PG J2 |
Physiological roles | Lipid catabolism and homeostasis (stimulating β-oxidation of fatty acids), increased breakdown of TG and FA, increased cellular FA uptake, reduced TG and FA synyheis, control of inflammatory processes, and vascular integrity mediate the hypolipidemic function of fibrates Liver: increasing FA oxidation and uptake and increasing apoA-I, apoA-II, and HDL Vessel: increasing TG, HDL, ABCA1, and apoE and decreasing FFA, VLDL, cytokines, and NF-κB | Dyslipidemia? Wound healing? Increasing fat oxidation in skeletal and cardiac muscle responsible for insulin sensitivity and glucose homeostasis and vascular integrity Adipocentric action: decreasing cytokines, resistin, fFFA, and NF-κB and increasing ABCA1 and GLUT4 Skeletal muscle: increasing glucose uptake and glycogen synthesis | Glucose homeostasis and lipid storage: differentiation and maturation of adipocytes Increasing IS and glucose homeostasis (it prevents hyperglycemia) and vascular integrity Skeletal muscle/liver/adipocyte: increasing FA oxidation, UCP, and HDL and decreasing TG |