Treatment with PPARα Agonist Clofibrate Inhibits the Transcription and Activation of SREBPs and Reduces Triglyceride and Cholesterol Levels in Liver of Broiler Chickens

Table 1

Composition of the experimental grower diets.

	Control group	Treatment group
Components (g/kg)
Maize	630	629
Fish meal	25	25
Wheat middlings	30	30
Soybean meal 44%	260	260
Sunflower oil	25	25
Limestone powder	10	10
Calcium hydrogen phosphate	14.8	14.8
Sodium chloride	2.5	2.5
Vitamin-mineral mix^1	1.2	1.2
DL-methionine	1	1
Choline chloride 50%	0.5	0.5
Clofibrate	—	1.0
Crude nutrients and energy content
Dry matter (%)	89.84	89.84
Metabolizable energy (MJ/kg)	13.3	13.3
Crude protein (%)	19.1	19.1
Crude fat (%)	5.5	5.5
Linoleic acid (%)	2.0	2.0
Crude fibre (%)	2.6	2.6
Calcium (%)	0.98	0.98
Available phosphorus (%)	0.49	0.49

¹The vitamin-mineral mix provided per kg of diet: 3.3 mg retinol, 0.033 mg cholecalciferol, 13.34 mg D-α-tocopheryl acetate, 0.5 mg menadione, 2.2 mg thiamine, 6.6 mg riboflavin, 5.5 mg pyridoxine, 0.01 mg cobalamin, 13.5 mg pantothenate, 0.2 mg biotin, 1.0 mg folic acid, 44 mg nicotinic acid, 350 mg magnesium, 9.6 mg copper, 100 mg iron, 108 mg manganese, 88 mg zinc, 0.23 mg selenium, and 0.4 mg iodine.