Review Article
Zebrafish as a Model to Study the Role of Peroxisome Proliferating-Activated Receptors in Adipogenesis and Obesity
Table 3
Comparison of PPARs between human, mouse, and zebrafish.
| PPAR | Human | Mouse | Zebrafish |
| PPARA | | | | Genes | 1 | 1 | 2 | Splice variants | 1 | 1 | 1 per gene | Isoforms | 1 | 1 | 1 per gene | Size (cds, bp) | 1,407 | 1,407 | pparaa: 1,413 pparab: 1,380 | Protein similarity to zebrafish | 67% for pparaa 74% for pparab | 65% for pparaa 71% for pparab | |
| PPARD | | | | Genes | 1 | 1 | 2 | Splice variants | 1 | 1 | 1 per gene | Isoforms | 1 | 1 | 1 per gene | Size (cds, bp) | 1,326 | 1,323 | pparda: 1,491 ppardb: 1,554 | Protein similarity to zebrafish | 71% for pparda 73% for ppardb | 70% for pparda 73% for ppardb | |
| PPARG | | | | Genes | 1 | 1 | 1 | Splice variants | 4 | 1 | 1 | Isoforms | 2 | 2 | 1 | Size (cds, bp) | PPARG1 = 1,434 PPARG2 = 1,518 | PPARG1 = 1,428 PPARG2 = 1,518 | pparg: 1,584 | Protein similarity to zebrafish | 67% | 67% | |
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