PPARγ and the Innate Immune System Mediate the Resolution of Inflammation

Figure 5

PPARγ and the resolution of inflammation. PPARγ and PPARγ ligands (denoted by green diamond) play roles in all stages of inflammation. Early on, PPARγ and its ligands decrease neutrophil recruitment and proinflammatory cytokine production. PPARγ and its ligands then act to promote neutrophil apoptosis and efferocytosis and induction from proinflammatory to anti-inflammatory production. Finally, macrophages move to an M2 phenotype and tissue repair is initiated to return to homeostasis.