Restoration of Endothelial Function in Pparα^−/− Mice by Tempol

Figure 1

Impaired endothelium-dependent relaxations in aortas of Pparα^−/− mice. Contractile response curves to prostaglandin F_2α (PGF_2α) and 5-hydroxytryptamine (5-HT) and relaxation response curves to acetylcholine (ACh) and sodium nitroprusside (SNP) on PGF_2α-precontracted aortic rings from wild type (WT) and Pparα^−/− mice. denotes statistical significance from WT mice (; animals). Data are means ± SEM.