Restoration of Endothelial Function in Pparα^−/− Mice by Tempol

Figure 3

Decreased NO bioavailability in Pparα^−/− mice. (a) Aortic rings from WT (top) and Pparα^−/− (bottom) were sectioned and stained with DAF-FM to detect NO. The white arrow indicates the endothelial layer where there is increased fluorescence in WT compared to Pparα^−/− aorta. (b) Summary data of the DAF-FM fluorescence of the endothelial layer of WT and Pparα^−/− aortas. denotes statistical significance from WT mice (; rings from 2 pairs of mice). Data are means ± SEM.

(a)

(b)