Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism

Figure 6

Crystal structures of sulfonamide containing PPARγ partial agonists. (a) Poseview map of INT131. (b) Crystal structure of INT131 bound to the PPARγ ligand binding domain. PDB: 3FUR [60]. (c) Poseview map of Compound 2. (d) Crystal structure of Compound 2 bound to the PPARγ ligand binding domain. PDB: 2G0G [58]. The branches of the ligand binding pocket have been labelled with Roman numerals.

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