PPARα Is Required for PPARδ Action in Regulation of Body Weight and Hepatic Steatosis in Mice

Figure 5

Genome-wide transcriptional profiling of GW501516 effects in various genetic models reveals strong correlation between liver gene expression after 5 days and successive weight gain rate after 2 weeks. Pattern of hepatic gene expression across the experimental genotypes in 5-day (bars graphs) and 2-week weight gain versus 5-day expression data for Abcc3 (a), Slc19a1 (b), Slc25a10 (c), Ly6d (d), S3-12 (e), and Igf1 (f) (scatter graphs). Each point on the scatter graph represents mean value of each group (control or treated versus expression value) for given gene, mice/group. Significance is indicated (; ; ; test).

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