PPARα Is Required for PPARδ Action in Regulation of Body Weight and Hepatic Steatosis in Mice

Table 1

List of the genes altered by GW501516 treatment in mouse liver.

Gene symbol	Entrez gene ID	Pearson	value	FDR	Gene description	Biological process
Abcc3	76408	−0.9649		0.003	ATP-binding cassette, subfamily C (CFTR/MRP)	Transmembrane transport
Slc19a1	20509	−0.9355		0.021	Solute carrier family 19 (sodium/hydrogen exchanger), member 1	Transmembrane transport
Slc25a10	27376	−0.9211		0.034	Solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter)	Transmembrane transport
Abcc4	239273	−0.9096		0.033	ATP-binding cassette, subfamily C (CFTR/MRP)	Transmembrane transport
Slc16a5	217316	−0.9003		0.035	Solute carrier family 16 (monocarboxylic acid transporters)	Transmembrane transport
Srd5a3	57357	−0.9229		0.038	Steroid 5 α-reductase 3	Steroid catabolism
Cbr1	12408	−0.9055		0.034	Carbonyl reductase 1	Redox reactions
Grpel1	17713	−0.8953		0.035	GrpE-like 1, nuclear gene encoding mitochondrial protein	Protein anabolism
Ripk4	72388	−0.9023		0.034	Receptor-interacting serine-threonine kinase 4	Phosphorylation
Serhl	68607	−0.9201		0.03	Serine hydrolase-like (Serhl), mRNA.	Peroxisome function
Atxn10	54138	−0.8938		0.034	Ataxin 10	Nervous system development
Chchd6	66098	−0.8978		0.033	Coiled-coil-helix-coiled-coil-helix domain containing 6	Mitochondrial function
Ly6d	17068	−0.9099		0.036	Lymphocyte antigen 6 complex, locus D	Lymphocyte differentiation
Unc119	22248	−0.9030		0.035	Unc-119 homolog (C. elegans)	Lymphocyte differentiation
S3-12	57435	−0.8770		0.048	Plasma membrane associated protein, S3-12	Lipid droplets coating
Gns	75612	−0.8952		0.033	Glucosamine (N-acetyl)-6-sulfatase	Glycosaminoglycan metabolic process
Gal3st1	53897	−0.8796		0.05	Galactose-3-O-sulfotransferase 1	Glycolipid synthesis
Cpsf1	94230	−0.8935		0.033	Cleavage and polyadenylation specific factor 1	Gene expression
Taf1d	75316	−0.8913		0.033	TATA box binding protein (Tbp) associated factor	Gene expression
Sox12	20667	−0.8786		0.05	SRY-box containing gene 12	Gene expression
S100a13	20196	−0.9524		0.007	S100 calcium binding protein A13	Cytokine secretion
Igf1	16000	0.8777		0.048	Insulin-like growth factor 1	Cell growth
Nrg4	83961	−0.8991		0.033	Neuregulin 4	Cell growth
Pmm1	29858	−0.9147		0.035	Phosphomannomutase 1P	Carbohydrate metabolism
Prune	229589	−0.8866		0.039	Prune homolog (Drosophila)	Carbohydrate metabolism
Tmem120a	215210	−0.9082		0.032	Transmembrane protein 120A
C230029F24Rik	442837	−0.9141		0.032	PREDICTED: Mus musculus RIKEN cDNA C230029F24
1600032L17Rik		−0.9001		0.033	PREDICTED: Mus musculus RIKEN cDNA 1600032L17
2410012H22Rik	69747	−0.8784	0.00017	0.049	PREDICTED: Mus musculus RIKEN cDNA 2410012H22

Genes were identified through correlation tests between microarray hepatic expression data from 5 days versus weight gain rate (% of initial body mass) after 2 weeks from several independent experiments.
FDR: false discovery rate.