Peroxisome Proliferator-Activated Receptor-γ Is Critical to Cardiac Fibrosis

Figure 1

Schematic structure of peroxisome proliferator-activated receptor-γ and its protein isoforms. A/B, C, D, and E/F indicate the N-terminal A/B domain containing a ligand-independent AF-1, the DNA-binding domain, the hinge region, and the C-terminal LBD containing AF-2, respectively. AF-1 is responsible for phosphorylation, while AF-2 promotes the recruitment of coactivators for gene transcription. PPAR: peroxisome proliferator-activated receptor; AF: activation function; DBD: DNA-binding domain; HD: hinge domain; LBD: ligand-binding domain. Figure adapted from [13].

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