Commonalities in the Association between PPARG and Vitamin D Related with Obesity and Carcinogenesis

Figure 2

The four players: this figure shows the interrelation between the four players: obesity, cancer, vitamin D system, and PPARG. Red arrow: harmful effects, which contribute to disease. Green arrow:positive effects, which contribute to health. Disease perpetuates itself damaging both nuclear receptors. Arrow’s width is in proportion with the strength and consistency of each association found in the literature. Dashed line: yet-to-be determined, preliminary, or hypothetical effects. Continuous line: in vitro/in vivo demonstrated effects. Right box: in green, actions mainly attributed to vitamin D, and in purple, actions classically attributed to PPARG. However, it is known that both agents exert every action illustrated in this box, in a higher or lower extent.