15-Deoxy-Δ^12,14-prostaglandin J₂ Induces Apoptosis and Upregulates SOCS3 in Human Thyroid Cancer Cells

Figure 5

SOCS3 and SOCS1 increased in TPC-1 cells treated with 15d-PGJ₂. TPC-1 cells were treated with 15d-PGJ₂ (9,8 μM) for 0 to 24 h. (a) shows the relative expression of SOCS3 (b), SOCS1 (c), and STAT3 (c) in the first two hours of treatment and decreased STAT3 four hours after the treatment (c). The date are presented as means ± standard deviation of three replicates from at least three independent tests. An asterisk indicates statistically significant difference from the control (; ).

(a)

(b)

(c)