Polymorphisms of the PPAR-γ (rs1801282) and Its Coactivator (rs8192673) Have a Minor Effect on Markers of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus
Table 1
Baseline clinical and biochemical characteristics of diabetic patients and controls.
Diabetic patients
Controls
Age (years)
61.38 ± 9.65
60.07 ± 9.18
0.07
Male gender (%)
338 (56.8)
92 (46.0)
0.008
DM duration (years)
11.25 ± 7.88
—
—
Smoking prevalence (%)
53 (8.91)
34 (17.0)
0.002
Statin therapy (%)
375 (63.0)
62 (31.0)
<0.001
Antihypertensive agents (%)
499 (83.8)
58 (29%)
<0.001
Waist circumference (cm)
108.65 ± 12.88
93.31 ± 13.18
<0.001
BMI (kg/m2)
30.96 ± 4.74
27.90 ± 4.42
0.16
Systolic blood pressure (mm Hg)
146.98 ± 19.98
143.3 ± 16.6
0.86
Diastolic blood pressure (mm Hg)
85.75 ± 11.62
84.7 ± 11.6
0.19
Fasting glucose (mmol/L)
8.04 ± 2.57
5.27 ± 0.87
<0.001
HbA1c (%)
7.89 ± 3.56
4.79 ± 0.29
<0.001
Total cholesterol (mmol/L)
4.70 ± 1.19
5.36 ± 1.08
<0.001
HDL cholesterol (mmol/L)
1.19 ± 0.35
1.43 ± 0.37
<0.001
LDL cholesterol (mmol/L)
2.63 ± 0.94
3.24 ± 0.98
<0.001
Triglycerides (mmol/L)
1.9 (1.2–2.7)
1.3 (0.9–1.9)
<0.001
hsCRP (mg/L)
2.2 (1.0–4.3)
1.3 (0.8–2.7)
<0.001
CIMT (μm)
958 ± 194
890 ± 212
0.007
DM: diabetes mellitus; hsCRP: high sensitivity C-reactive protein.
