Polymorphisms of the PPAR-γ (rs1801282) and Its Coactivator (rs8192673) Have a Minor Effect on Markers of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus

Table 3

Ultrasonographic markers of carotid atherosclerosis due to rs1801282 genotypes in patients with T2DM at the time of recruitment.

Pro12AlaPPAR	CC	GC + GG
CIMT (μm)	1006 ± 210	1026 ± 209	0.39
Number of sites with plaque	2.56 ± 1.57	2.36 ± 1.82	0.31
Total plaque thickness (mm)	7.98 ± 4.47	7.65 ± 4.64	0.58
Presence of plaques
+	365 (86.5)	133 (76.9)	0.005
−	57 (13.5)	40 (23.1)
Presence of unstable plaques
+	213 (58.4)	74 (55.6)	0.61
−	152 (41.6)	59 (44.4)
Coronary calcium score	250 ± 315	269 ± 367	0.1
Number of coronary arteries with more than 50% stenosis	0.7 ± 0.9	0.9 ± 1.2	0.4
The presence of at least 1 vessel with more than 50% stenosis	24 (38.9%)	63 (41.1%)	0.2

Coronary computed tomography angiography (CCTA) was performed for diagnostic purposes in 215 out of 595 subjects with T2DM.