Polymorphisms of the PPAR-γ (rs1801282) and Its Coactivator (rs8192673) Have a Minor Effect on Markers of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus
Table 4
Ultrasonographic markers of carotid atherosclerosis due to rs8192673 genotypes in patients with T2DM at the time of recruitment.
TT
TC
CC
CIMT (μm)
1007 ± 224
1012 ± 191
1012 ± 217
0.94
Number of sites with plaque
2.36 ± 1.60
2.69 ± 1.66
2.72 ± 1.67
0.13
Total plaque thickness (mm)
7.54 ± 4.54
8.06 ± 4.82
8.31 ± 4.35
0.35
Presence of plaques
+
257 (83.2)
194 (84.0)
47 (85.5)
0.90
−
52 (16.8)
37 (16.0)
8 (14.5)
Presence of unstable plaques
+
149 (58.0)
108 (55.7)
29 (61.7)
0.73
−
108 (42.0)
86 (44.3)
18 (38.3)
Coronary calcium score
181 ± 170
344 ± 376
200 ± 304
0.2
Number of coronary arteries with more than 50% stenosis
0.7 ± 1.1
0.9 ± 1.1
0.6 ± 1.3
0.8
The presence of at least 1 vessel with more than 50% stenosis
7 (31.8%)
33 (39.3%)
48 (44.0%)
0.3
Coronary computed tomography angiography (CCTA) was performed for diagnostic purposes in 215 out of 595 subjects with T2DM.
