Polymorphisms of the PPAR-γ (rs1801282) and Its Coactivator (rs8192673) Have a Minor Effect on Markers of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus
Table 5
Association of the rs1801282 genotypes with the presence of plaques and presence of unstable plaques in patients with T2DM at the time of recruitment.
Presence of plaque
Presence of unstable plaque
OR (95% CI)
OR (95% CI)
rs1801282
Hypertension (0 = no; 1 = yes)
1.71 (0.93–2.58)
0.04
1.25 (0.88–2.64)
0.97
Systolic blood pressure (mm Hg)
1.07 (0.92–1.007)
0.17
1.11 (0.86–1.44)
0.32
LDL cholesterol (mmol/L)
1.21 (0.78–1.89)
0.40
1.08 (0.75–1.56)
0.67
HDL cholesterol (mmol/L)
0.18 (0.05–0.63)
0.008
0.30 (0.08–1.13)
0.08
Triglycerides (mmol/L)
1.28 (0.63–1.03)
0.09
1.09 (0.66–1.37)
0.34
Hba1c (%)
1.14 (0.64–1.54)
0.28
1.22 (0.74–1.92)
0.42
GC + GG
0.79 (0.48–1.14)
0.04
0.83 (0.34–1.91)
0.65
rs8192673
Hypertension (0 = no; 1 = yes)
1.35 (1.13–1.93)
0.04
1.15 (0.75–2.77)
0.79
Systolic blood pressure (mm Hg)
1.08 (0.96–1.34)
0.16
1.02 (0.97–1.25)
0.31
LDL cholesterol (mmol/L)
1.22 (0.78–1.89)
0.29
1.07 (0.74–1.54)
0.73
HDL cholesterol (mmol/L)
0.19 (0.05–0.72)
0.54
0.29 (0.08–1.05)
0.06
Triglycerides (mmol/L)
1.34 (0.63–1.90)
0.09
1.19 (0.66–1.59)
0.34
Hba1c (%)
1.16 (0.65–2.06)
0.32
1.11 (0.86–1.44)
0.42
TC
0.97 (0.56–1.38)
0.48
1.16 (0.59–2.70)
0.55
CC
1.08 (0.38–1.34)
0.63
1.43 (0.43–4.73)
0.56
All the models were adjusted for age, gender, smoking, and statin treatment. Reference group were homozygotes for allele C. Reference group were homozygotes for allele T.
