Polymorphisms of the PPAR-γ (rs1801282) and Its Coactivator (rs8192673) Have a Minor Effect on Markers of Carotid Atherosclerosis in Patients with Type 2 Diabetes Mellitus
Table 6
Association of the rs1801282 genotypes with ultrasonographic markers of carotid atherosclerosis progression in patients with T2DM.
CIMT progression rate
Δ Number of sites with plaque
Δ Total plaque thickness
rs1801282
Hypertension (0 = no; 1 = yes)
0.013
0.92
0.020
0.90
0.069
0.26
Systolic blood pressure (mm Hg)
0.022
0.52
0.052
0.69
0.037
0.82
LDL cholesterol (mmol/L)
0.057
0.69
0.051
0.71
0.073
0.49
HDL cholesterol (mmol/L)
−0.211
0.19
−0.230
0.14
−0.189
0.37
Triglycerides (mmol/L)
0.249
0.13
0.343
0.78
0.359
0.44
Hba1c (%)
1.151
0.29
1.097
0.83
1.176
0.41
GC + GG
0.818
0.93
0.728
0.18
0.684
0.16
rs8192673
Hypertension (0 = no; 1 = yes)
0.140
0.37
0.062
0.71
0.069
0.29
Systolic blood pressure (mm Hg)
0.186
0.25
0.046
0.88
0.075
0.35
LDL cholesterol (mmol/L)
0.172
0.59
0.143
0.75
0.446
0.35
HDL cholesterol (mmol/L)
−0.203
0.18
−0.232
0.08
−0.192
0.34
Triglycerides (mmol/L)
0.168
0.28
0.117
0.43
0.127
0.21
Hba1c (%)
0.146
0.27
0.143
0.26
0.228
0.16
TC
0.068
0.63
−0.066
0.64
0.328
0.32
CC
0.349
0.01
−0.115
0.11
0.681
0.06
All the models were adjusted for age, gender, smoking, statin treatment and baseline value of dependent variable. Reference group were homozygotes for the allele C; Reference group were homozygotes for the allele T.
