The Correlation of PPARα Activity and Cardiomyocyte Metabolism and Structure in Idiopathic Dilated Cardiomyopathy during Heart Failure Progression

Table 3

Morphometric data.

	Control; (); LVEF > 60%	Group (I); (); LVEF 50–45%	Group (II); (); LVEF 41–30%	Group (III); (); LVEF < 30%
Myocyte cross-sectional area [m^2]	415 ± 48	452 ± 83	548 ± 94	526 ± 127
Myocyte longitudinal area [µm^2]	1294 ± 146	1642 ± 198	2094 ± 458	2298 ± 477
Myocyte degeneration [%]	0.28 ± 0.1	1.25 ± 0.9	6.72 ± 3.5	10.23 ± 4.6
Desmin dominated pattern	I	IIA	IIB	III
Myocyte death
Apoptotic []	0	0.03 ± 0.004	0.05 ± 0.008	0.02 ± 0.001
Autophagic []	0.4 ± 0.02	1.01 ± 0.8	3.5 ± 2.18	7.92 ± 2.39
Glycogen storage (final score)	Normal	Low	Severe	Moderate
Ultrastructural pathology (final score)	No	Mild	Moderate	Severe

  versus control group, versus Group (I).