Differential Roles of Peroxisome Proliferator-Activated Receptor-α and Receptor-γ on Renal Crystal Formation in Hyperoxaluric Rodents
Table 1
Physical characteristics and serum and urinary biochemistry of experimental rats on day 14.
Physical findings
Control
EG
EG + α
EG + γ
EG + αγ
Body weight gain (g)
92.0 ± 4.6
81.0 ± 4.0
53.8 ± 3.4
66.8 ± 3.1
63.2 ± 2.7
Kidney weight (g)
2.3 ± 0.1
3.3 ± 0.4
4.4 ± 0.1
2.5 ± 0.1
4.4 ± 0.2
Serum biochemistries
Control
EG
EG + α
EG + γ
EG + αγ
Cr (mg/dL)
0.25 ± 0.01
0.30 ± 0.03
0.44 ± 0.03
0.28 ± 0.02
0.47 ± 0.04
Ca (mg/dL)
10.2 ± 0.1
10.7 ± 0.1
10.2 ± 0.1
10.4 ± 0.2
10.2 ± 0.1
P (mg/dL)
8.4 ± 0.5
8.0 ± 0.1
9.9 ± 0.3
7.6 ± 0.1
8.8 ± 0.1
BS (mg/dL)
146 ± 6
148 ± 2
142 ± 6
123 ± 7
127 ± 3
TG (mg/dL)
36 ± 2
41 ± 10
39 ± 9
47 ± 8
43 ± 9
TC (mg/dL)
56 ± 2
54 ± 2
45 ± 3
52 ± 2
33 ± 3
Urine biochemistries
Control
EG
EG + α
EG + γ
EG + αγ
Volume (mL)
11 ± 1
29 ± 5
28 ± 2
24 ± 3
21 ± 3
pH
7.8 ± 0.1
7.6 ± 0.3
7.3 ± 0.2
7.6 ± 0.2
7.3 ± 0.3
Ca (nmol/g/Cr)
86 ± 11
43 ± 6
43 ± 3
43 ± 7
31 ± 6
P (µmol/g/Cr)
2.6 ± 0.3
2.6 ± 0.7
2.8 ± 0.7
2.7 ± 0.2
2.6 ± 0.3
Ox (µmol/g/Cr)
24 ± 3
201 ± 27
343 ± 40
230 ± 37
229 ± 30
Mean ± standard error (SE). compared with the control group; compared with the EG group. Data of control, EG, and EG + γ groups were obtained by our previous study [26]. Cr, creatinine; Ca, calcium; P, phosphorus; BS, blood sugar; TG, triglyceride; TC, total cholesterol; Ox, oxalate.
