Activation and Expression of Peroxisome Proliferator-Activated Receptor Alpha Are Associated with Tumorigenesis in Colorectal Carcinoma

Figure 4

PPAR- activation affects apoptosis. (a) Control in Caco-2 cells (200×). (b) 100 μM of fenofibrate in Caco-2 cells (200×). (c) 100 μM of fenofibrate and 3 μM of GW6471 in Caco-2 cells (200×). (d) Control in SW620 cells (200×). (e) 100 μM of fenofibrate in SW620 cells (200×). (f) 100 μM of fenofibrate and 3 μM of GW6471 in SW620 cells (200×). (g) Human colorectal carcinoma cells (Caco-2 and SW620) were treated with 100 μM of fenofibrate, and 100 μM of fenofibrate and 3 μM of GW6471 for 48 h; apoptosis was determined by a Hoechst stain. Error bars indicate standard deviation.

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