Molecular Aspects of H. pylori-Related MALT Lymphoma
Table 1
Cytogenetic abnormalities in gastric MALT lymphomas, along with their reported frequencies, known clinical implications and available assays for their detection.
Abnormality
% Gastric MALT
Clinical implications
Available assay(s)
t(11;18)(q21;q21)
Up to 25%
Antibiotic resistance
FISH; RT-PCR; BCL10 IHC (nuclear)
t(14;18)(q32;q21)
Up to 5%
Unknown
FISH; PCR; MALT1 and BCL10 IHC (cytoplasmic/perinuclear)
t(1;14)(p22;q32)
Rare
Antibiotic resistance
BCL10 IHC (nuclear)
t(3;14)(q27;q32)
Rare
Reported in DLBCL with concurrent MALT
FISH (break-apart); BCL6 IHC (only 25%–30%)
Trisomies
5%–65%, depending on series
3q27 most common; associated with high-stage disease