Morphological Analysis of CDC2 and Glycogen Synthase Kinase 3β Phosphorylation as Markers of G2 → M Transition in Glioma
Figure 3
pTyr15CDC2 levels in glial tumors. Tissue arrays for GBM (a–c), oligodendroglioma (d–f), and ependymoma (g–h) were stained with anti-pTyr15CDC2 antibodies. Panel (i) demonstrates immunostaining in cortex of a control sample. Groups were separated into low labeling (a, d, and g), intermediate labeling (b, e, and h), and high labeling (c, and f) representative photographs are illustrated. Bottom left of each panel shows the total number of cores () and their proportion of total cores for the low, intermediate, and high labeling group. No cores of ependymoma showed high pTyr15CDC2 labeling. (GBM = glioblastoma; Oligo = oligodendroglioma; EP = ependymoma; scale bar in yellow represents 100 μm).
