Genetic Polymorphism of Cancer Susceptibility Genes and HPV Infection in Cervical Carcinogenesis

Table 1

Frequency of high-risk HPV and GSTM1, GSTT1 polymorphisms in exfoliated cervical cell samples.

Lesions	Number with high-risk HPV	GSTM1null	GSTT1 null
Normal (𝑛=54)	10 (18.5%)^a	28 (51.9%)	24 (44.4%)^c
LSIL (𝑛=102)	28 (27.5%)^b	55 (53.9%)	40 (39.2%)^d
HSIL (𝑛=42)	31 (73.8%)^a, b	20 (47.6%)	29 (69.0%)^c, d

^a𝑃<.0001, OR = 12.4 𝜒²  versus normal. ^b𝑃<.0001, OR = 7.4 𝜒² versus LSIL. ^c𝑃=.0162, OR = 2.8 𝜒²  versus normal. ^d𝑃=.0011, OR = 3.5 𝜒²  versus LSIL.