Genetic Polymorphism of Cancer Susceptibility Genes and HPV Infection in Cervical Carcinogenesis

Table 3

Frequency of high-risk HPV and p53 codon 72 polymorphism in exfoliated cervical cell samples.

Lesions	Number with; high-risk HPV	Aminoacid at p53 codon 72
		Arg	Arg/Pro	Pro
Normal (𝑛=54)	10 (18.5%)^a	24 (44.4%)	23 (42.6%)	7 (13.0%)
LSIL (𝑛=102)	28 (27.5%)^b	38 (37.3%)	40 (39.2%)	24 (23.5%)
HSIL (𝑛=42)	31 (73.8%)^a, b	18 (42.9%)	16 (38.1%)	8 (19.0%)

^a𝑃<.0001, OR = 12.4 𝜒²  versus normal. ^b𝑃<.0001, OR = 7.4 𝜒²  versus LSIL.