Genetic Polymorphism of Cancer Susceptibility Genes and HPV Infection in Cervical Carcinogenesis

Table 5

Frequency of high-risk HPV and MDM2-SNP309 in exfoliated cervical cell samples.

Lesions	Number with high-risk HPV	Genotype frequency		Allele frequency
		TT	TG + GG	T	G
Normal (𝑛=52)	10 (19.2%)^a	11 (21.2%)	41 (78.8%)	49 (47.2%)	55 (52.8%)
LSIL (𝑛=102)	28 (27.5%)^b	26 (25.4%)	76 (74.6%)	104 (50.6%)	100 (49.4%)
HSIL (𝑛=41)	30 (73.2%)^a, b	7 (17.1%)	34 (82.9%)	37 (45.1%)	45 (54.9%)

^a𝑃=.0010  𝜒²  versus normal. ^b𝑃=.0019  𝜒²  versus LSIL.