Genetic Polymorphism of Cancer Susceptibility Genes and HPV Infection in Cervical Carcinogenesis

Table 8

Frequency of high-risk HPV and Fas promoter -670 polymorphism in exfoliated cervical cell samples.

Lesions	Number with high-risk HPV	Genotype frequency		Allele frequency
		AA	GA + GG	A	G
Normal (𝑛=63)	10 (15.9%)^a	19 (30.2%)	44 (69.8%)^c	67 (53.2%)	59 (46.8%)^e
LSIL (𝑛=167)	46 (27.5%)^b	51 (30.5%)	116 (69.5%)^d	165 (49.4%)	169 (50.6%)^f
HSIL	40 (81.6%)^a, b	5 (10.2%)	44 (89.8%)^c, d	37 (37.8%)	61 (62.2%)^e, f

^a𝑃<.0001 𝜒² versus normal, ^b𝑃<.0001 𝜒² versus LSIL,
^c𝑃=.0107  𝜒² versus normal, ^d𝑃=.0043 𝜒² versus LSIL,
^e𝑃=.0217 𝜒² versus normal, ^f𝑃=.0422𝜒² versus LSIL.