Research Article

Molecular Phenotypes of Unifocal, Multifocal, and Diffuse Invasive Breast Carcinomas

Table 1

Immunophenotypic parameters, histology grade and node status by invasive tumor distribution (unifocal, multifocal, and diffuse) in 875 consecutive breast cancer cases, Falun 2005–2009.

PhenotypeInvasive tumor distributionSignificance level
UnifocalMultifocalDiffuseTotalUnifocal versus multifocalUnifocal versus diffuse

ER positive83.1% (423/509)81.8% (256/313)97.7% (42/43)83.4% (721/865) 𝑃 = . 7 8 5 2 𝑃 = . 0 1 7 8
PR positive66.3% (331/499)64.9% (203/313)53.5% (23/43)65.1% (557/855) 𝑃 = . 8 2 8 9 𝑃 = . 1 5 6 5
HER2 positive9.6% (48/501)15.2% (48/315)4.8% (2/42)11.4% (98/858) 𝑃 = . 0 4 1 9 𝑃 = . 4 3 3 4
Triple negative11.2% (56/499)10.5% (33/313)2.4% (1/42)10.5% (90/854) 𝑃 = . 9 0 8 3 𝑃 = . 1 1 4 4
Basal-like12.5% (37/296)11.3% (22/195)3.7% (1/27)11.6% (60/518) 𝑃 = . 6 0 2 0 𝑃 = . 2 8 9 6
Grade 322.6% (115/509)25.2% (80/318)7.0% (3/43)22.8% (198/870) 𝑃 = . 5 6 6 4 𝑃 = . 0 2 4 5
Node positive27.3% (140/513)54.2% (173/319)55.8% (24/43)38.5% (337/875) 𝑃 < . 0 0 0 1 𝑃 = . 0 0 0 1