Novel Molecular Markers of Malignancy in Histologically Normal and Benign Breast
Figure 4
Serial archival sections representative of a histologically normal breast tissues with low-grade molecular abnormality stained for H&E, TOP2A, MCM2 and BUB1B proteins. (a) Portion of a TDLU from a molecularly low-risk, histologically normal breast tissue (Case 8, specimen 1481). Serial sections showing the same TDLU as in (a) without any expression of TOP2A (b) and MCM2 (c) in the epithelial cell nuclei. There is a focal cytoplasmic immunoreactivity (1+ to 2+) for BUB1B protein (d) in some of the mammary epithelial cells in this field. (IMPOX staining; original magnifications 200x).
