Research Article
Novel Molecular Markers of Malignancy in Histologically Normal and Benign Breast
Table 3
Mean TOP2A and MCM2 indices and BUB1B protein expression scores in IDCs and molecularly high-risk and low-risk, histologically normal breast tissues.
| | Archival specimen type | Average no. of TDLUs evaluated/specimen (Range) | Mean TOP2A index (%) by IHC | Mean MCM2 index (%) by IHC | Mean BUB1B protein expression score (H-score) by IHC (Range) |
| | IDCs () | Not applicable | 27 (15–35) | 47 (30–80) | 149 (80–200) | | Histologically normal breast tissues with high-grade molecular abnormality () on microarray | 31 (6–39) | 11 (2–30) | 20 (8–35) | 68 (33–113) | | Histologically normal breast tissues with low-grade molecular abnormality () on microarray | 24 (17–35) | 2 (1–3) | 4 (1–12) | 17 (10–22) | | value | .18 | <.005 | <.05 | <.005 |
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