Molecular Characteristics of Pancreatic Ductal Adenocarcinoma

Table 3

Hereditary syndromes associated with an increased risk of PDAC development.

Syndrome	Affected gene(s)	Relative risk of PDAC
Familial atypical multiple melanoma and mole syndrome	CDKN2A	20–34
Peutz-Jeghers syndrome	LKB1	>100
Hereditary pancreatitis	PRSS1/SPINK1	~90
Familial breast cancer	BRCA1/2	3–10
Lynch syndrome	mismatch repair genes	unknown