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Pathology Research International
Volume 2011 (2011), Article ID 743836, 6 pages
http://dx.doi.org/10.4061/2011/743836
Research Article

Histological Correlation of Glandular Abnormalities in Cervical Liquid-Based Cytology

1Institute for Clinical Research, National Hospital Organization Japan, Kure Medical Center/Chugoku Cancer Center, 3-1 Aoyama-Cho, Kure-City, Hiroshima 737-0023, Japan
2Department of Obstetrics and Gynecology, National Hospital Organization Japan, Kure Medical Center/Chugoku Cancer Center, 3-1 Aoyama-Cho, Kure-City, Hiroshima 737-0023, Japan
3Department of Diagnostic Pathology, National Hospital Organization Japan, Kure Medical Center/Chugoku Cancer Center, 3-1 Aoyama-Cho, Kure-City, Hiroshima 737-0023, Japan

Received 2 February 2011; Accepted 12 June 2011

Academic Editor: Nirag Jhala

Copyright © 2011 Yosuke Kawakami et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Conventional Papanicolaou smear method is still commonly used for cervical cancer screening in Japan, despite the liquid-based cytology (LBC) that has become a global tendency in the world recently. One of the obstacles in the way of popularization of this method seems to be the confusion as to diagnosis upon cervical glandular lesions. We performed comparison study between LBC and conventional Papanicolaou smear about cytological diagnosis using split-sample method in 4522 patients. In 13 cases analyses, which were reported with either AGC or adenocarcinoma by either method, LBC tends to be milder than that by conventional smear, however, the credibility of LBC is considered to be near to that of conventional smear with regard to screening for glandular abnormalities. These results indicate that cervical cancer screening should shift to LBC under the enough experience and appropriate dealing with the cytological diagnosis.