Review Article

Hereditary Diffuse Gastric Cancer: Multidisciplinary Case Report with Review of the Literature

Table 1

(Updated) Criteria for CDH1 molecular genetic testing.

Two or more cases of gastric cancer in a family, with at least one histologically confirmed diffuse gastric cancer (DGC) diagnosed before the age of 50.
Three or more confirmed cases of DGC in 1st or 2nd degree relatives, independent of age of onset.
An individual diagnosed with DGC before the age of 40.
An individual or family members diagnosed with DGC and lobular breast cancer, one being diagnosed before the age of 50.