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| Gross | Low Power | High Power |
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| Smear | Composition | Aggregates | Cell Size | Nuclei | Nucleoli | Chromatin | Cytoplasm | Mitotic activity | Plasma/-cytoid Cells | Mast Cells | Other Cells |
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RLH | Large and small aggregates | Polymorphic | LHA and FCF are key features | Small to intermediate | N/A | N/A | N/A | N/A | Present | Present | Present | Complete spectrum |
MZL | Large and small aggregates | Polymorphic | LHA and FCF possible | Intermediate | Smooth to mildly irregular | Inconspicuous to large | Open to clumped | Conspi-cuous, abundant in monocytoid forms | Low | Present | Present | Large activated cells, histiocytes, immunoblasts |
FL Grade 1/2 | Numerous small aggregates | Monomorphic to dimorphic (grades 1-2) | Repetitive FCF common | Intermediate | Irregular, bilobed or “divided” nuclei common | Inconspicuous | Open to clumped | Scant | Low | Absent | Present | Centroblasts |
MCL | Vague aggregates | Markedly monomorphic | Vague aggregates (FCF/LHA possible in mantle zone pattern) | Intermediate (small and large cell variants occur) | Subtly irregular | Inconspicuous to large | Dispersed to clumped | Variable, moderate | Possible | Absent/ Rare | Infrequent | Scattered EH present, PLC and PIB absent |
SLL/CLL | Vague aggregates | Monomorphic | Vague aggregates (proliferation centers) | Small | Smooth | Absent/In-conspicuous | Coarse -clumped | Scant | Low | Infrequent | Infrequent | PLC, PIB, smudge cells, rarely RS cells |
LPL | Vague aggregates | Mono-, rarely polymorphic | Rare/ Absent aggregates | Small | Smooth, possible Dutcher bodies | Absent/In-conspicuous | Coarse–clumped, “cart-wheel” | Scant to plasma-cytoid, Russell bodies | Low | Common | Present, often frequent | PLC and PIB absent |
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