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Pathology Research International
Volume 2012 (2012), Article ID 169270, 5 pages
http://dx.doi.org/10.1155/2012/169270
Review Article

Neuroinflammation as the Proximate Cause of Signature Pathogenic Pattern Progression in Amyotrophic Lateral Sclerosis, Aids, and Multiple Sclerosis

Department of Pathology, Mater Dei Hospital, University of Malta Medical School, Msida MSD 2090, Malta

Received 15 July 2012; Accepted 12 November 2012

Academic Editor: Gary Tse

Copyright © 2012 Lawrence M. Agius. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. V. Pizza, A. Agresta, C. W. ĎAcunto, M. Festa, and A. Capasso, “Neuroinflamm-aging and neurodegenerative diseases: an overview,” CNS and Neurological Disorders, vol. 10, no. 5, pp. 621–634, 2011. View at Scopus
  2. W. Sako, H. Ito, M. Yoshida, et al., “Nuclear factor kB expression in patients with sporadic amyotrophic lateral sclerosis and hereditary amyotrophic lateral sclerosis with optineurin mutations,” Clinical Neuropathology, vol. 31, no. 6, pp. 418–423, 2012.
  3. M. R. Jablonski, D. A. Jacob, C. Campos et al., “Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacoresistance in ALS,” Neurobiology of Disease, vol. 47, no. 2, pp. 194–200, 2012. View at Publisher · View at Google Scholar
  4. N. Ticozzi, C. Tiloca, N. E. Mencacc, et al., “Oligoclonal bands in the cerebrospinal fluid of amyotrophic lateral sclerosis patients with disease-associated mutations,” Journal of Neurology. In press.
  5. B. Liao, W. Zhao, D. R. Beers, J. S. Henkel, and S. H. Appel, “Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS,” Experimental Neurology, vol. 237, no. 1, pp. 147–152, 2012. View at Publisher · View at Google Scholar
  6. S. H. Appel, W. Zhao, D. R. Beers, and J. S. Henkel, “The microglial-motoneuron dialogue in ALS,” Acta Myologica, vol. 30, no. 1, pp. 4–8, 2011. View at Scopus
  7. C.-A. Lewis, J. Manning, F. Rossi, and C. Krieger, “The neuroinflammatory response in ALS: the roles of microglia and T cells,” Neurology Research International, vol. 2012, Article ID 803701, 2012. View at Publisher · View at Google Scholar
  8. A. Contestabile, “Amyotrophic lateral sclerosis: from research to therapeutic attempts and therapeutic perspectives,” Current Medicinal Chemistry, vol. 18, no. 36, pp. 5655–5665, 2011.
  9. D. W. Williams, E. A. Eugenin, T. M. Calderon, and J. W. Berman, “Monocyte maturation, HIV susceptibility, and transmigration across the blood brain barrier are critical in HIV neuropathogenesis,” Journal of Leukocyte Biology, vol. 91, no. 3, pp. 401–415, 2012. View at Publisher · View at Google Scholar
  10. T. Philips and W. Robberecht, “Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease,” The Lancet Neurology, vol. 10, no. 3, pp. 253–263, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. J. Patel and R. Balabanov, “Molecular mechanisms of oligodendrocyte injury in multiple sclerosis and experimental autoimmune encephalomyelitis,” International Journal of Molecular Sciences, vol. 13, no. 8, pp. 10647–10659, 2012.
  12. J. V. Berger, A. O. Dumont, M. C. Focant, et al., “Opposite regulation of metabotrophic glutamate receptor 3 and metabotropic glutamate receptor 5 by inflammatory stimuli in cultured microglia and astrocytes,” Neuroscience, vol. 205, pp. 29–38, 2012. View at Publisher · View at Google Scholar
  13. J. Aebischer, A. Moumen, V. Sazdovitch, D. Seilhean, V. Meininger, and C. Raoul, “Elevated levels of IFNy and LIGHT in the spinal cord of patients with sporadic amyotrophic lateral sclerosis,” European Journal of Neurology, vol. 19, no. 5, pp. 752–759, 2012.
  14. K. Williams and T. H. Burdo, “Monocyte mobilization, activation markers, and unique macrophage populations in the brain: observations from SIV Infected monkeys are informative with regard to pathogenic mechanisms of HIV infection in humans,” Journal of Neuroimmune Pharmacology, vol. 7, no. 2, pp. 363–371, 2012. View at Publisher · View at Google Scholar
  15. G. Li, M. M. Esiri, O. Ansorge, and G. C. DeLuca, “Concurrent multiple sclerosis and amyotrophic lateral sclerosis: where inflammation and neurodegeneration meet?” Journal of Neuroinflammation, vol. 9, Article ID 20, 2012. View at Publisher · View at Google Scholar
  16. M. Krumbholz, T. Derfuss, R. Hohlfeld, and E. Meinl, “B cells and antibodies in multiple sclerosis pathogenesis and therapy,” Nature Reviews Neurology, vol. 8, no. 11, pp. 613–623, 2012. View at Publisher · View at Google Scholar
  17. Y. Karmon, M. Ramanathan, A. Minagar, R. Zivadinov, and B. Weinstock-Guttman, “Arterial, venous and other vascular risk factors in multiple sclerosis,” Neurological Research, vol. 34, no. 8, pp. 754–760, 2012. View at Publisher · View at Google Scholar
  18. T. Valente, P. Mancera, J. M. Tusell, J. Serratosa, and J. Saura, “C/EBPβ expression in activated microglia in amyotrophic lateral sclerosis,” Neurobiology of Aging, vol. 33, no. 9, pp. 2186–2199, 2012. View at Publisher · View at Google Scholar
  19. H. Lassmann, J. van Horssen, and D. Mahad, “Progressive multiple sclerosis: pathology and pathogenesis,” Nature Reviews Neurology, vol. 8, no. 11, pp. 647–656, 2012. View at Publisher · View at Google Scholar
  20. P. S. Khansari and B. Sperlagh, “Inflammation in neurological and psychiatric diseases,” Inflammopharmacology, vol. 20, no. 3, pp. 103–107, 2012. View at Publisher · View at Google Scholar
  21. D. Buassat, “When does multiple sclerosis start? Three case reports and a review of the literature,” Revue Neurologique, vol. 168, no. 11, pp. 846–851, 2012. View at Publisher · View at Google Scholar
  22. A. Finkelstein, G. Kunis, A. Seksenyan et al., “Abnormal changes in NKT cells, the IGF-1 axis, and liver pathology in an animal model of ALS,” PLoS One, vol. 6, no. 8, Article ID e22374, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. A. Wada, “Roles of voltage-dependent sodium channels in neuronal development, pain, and neurodegeneration,” Journal of Pharmacological Sciences, vol. 102, no. 3, pp. 253–268, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. V. Swarup, D. Phaneuf, C. Barcil, et al., “Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments,” Brain, vol. 134, part 9, pp. 2610–2626, 2011.
  25. M. Casula, A. M. Iyer, W. G. M. Spliet et al., “Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue,” Neuroscience, vol. 179, pp. 233–243, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. R. Bingham, N. Ahmed, P. Rangi, M. Johnson, M. Tyrer, and J. Green, “HIV encephalitis despite suppressed viraemia: a case of compartmentalized viral escape,” International Journal of STD and AIDS, vol. 22, no. 10, pp. 608–609, 2011. View at Publisher · View at Google Scholar
  27. K. M. Doyle, D. Kennedy, A. M. Gorman, S. Gupta, S. J. M. Healy, and A. Samali, “Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders,” Journal of Cellular and Molecular Medicine, vol. 15, no. 10, pp. 2025–2039, 2011. View at Publisher · View at Google Scholar
  28. D. K. Kaushik, M. Gupta, and A. Basu, “Microglial response to viral challenges: every silver lining comes with a cloud,” Frontiers in Bioscience, vol. 16, no. 6, pp. 2187–2205, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. P. I. Joyce, P. Fratta, E. M. C. Fisher, and A. Acevedo-Arozena, “SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments,” Mammalian Genome, vol. 22, no. 7-8, pp. 420–448, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. C. Volonté, S. Apolloni, M. T. Carrì, and N. D'Ambrosi, “ALS: focus on purinergic signalling,” Pharmacology and Therapeutics, vol. 132, no. 1, pp. 111–122, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. P. Grammas, J. Martinez, and B. Miller, “Cerebral microvascular endothelium and the pathogenesis of neurodegenerative diseases,” Expert Reviews in Molecular Medicine, vol. 13, p. e19, 2011. View at Publisher · View at Google Scholar
  32. M. C. Evans, Y. Couch, and N. Sibson, “Inflammation and neurovascular changes in amyotrophic lateral sclerosis,” Molecular and Cellular Neuroscience. In press.