Pathology Research International

Clinical Study

Gastric Composite Tumor of Alpha Fetoprotein-Producing Carcinoma/Hepatoid Adenocarcinoma and Endocrine Carcinoma with Reference to Cellular Phenotypes

Table 4

Immunohistochemical findings of AFP-producing carcinoma and neuroendocrine carcinoma of the stomach.
CaseHistologyNCAMCGASPNSEAFPMUC2MUC5ACMUC6CDX2SOX2Ki67 labeling index (%)Phenotype
Tubular−−−−+−−−−+16Gastric
1Hepatoid−−−−+−−+−+12Gastric
LCNEC−++−−−++++42Mixed
2LCNEC+++−−−−+−+24Gastric
3LCNEC++++−−−+−+32Gastric
4LCNEC+−+−−+++−+22Mixed
5LCNEC−−+−−−−−−+23Gastric
6SCNEC−−++−−−−−−32Null
7SCNEC−+++−−−+−+25Gastric
8AFPC−−−−++−−+−35Intestinal
9AFPC−−−−+−+++−18Mixed
10AFPC−−−−+−++++8Mixed
11AFPC−−−−+−+++−12Mixed
LCNEC, large-cell neuroendocrine carcinoma;
SCNEC, small-cell neuroendocrine carcinoma;
AFPC, alfa fetoprotein-producing carcinoma;
NCAM, neural-cell adhesion molecule;
CGA, chromogranin A;
SP, synaptophysin;
NSE, neuron-specific enolase;
AFP, alfa fetoprotein.