Barrett’s Esophagus: Emerging Knowledge and Management Strategies

Table 3

Incidence of esophageal adenocarcinoma in high-grade dysplasia*.

Study (reference)	Number of patients with HGD	Duration of followup	Incidence of EAC
Schnell et al. [47]	75 HGD patients who didn’t have EAC after 1 year f/u	7.3 years (mean)	12/75 (16%) during 7 years; 2.19% per year
Weston et al. [48]	15 patients with unifocal HGD	36.8±23.2 months (mean)	4/15 (26.7%) during f/u; ~8.7% per year
Rastogi et al. [49]	236 HGD patients (meta-analysis of 4 studies)	1241 patient years	Crude = 5.57% per year; weighted = 6.58% per year

*Includes some of the important studies, not intended to include all studies published in the literature; f/u: followup; HGD: high-grade dysplasia; EAC: esophageal adenocarcinoma.