Genetics of Behçet's Disease

Table 1

Findings supporting the genetic background of Behçet’s disease.

Studies	Findings/associations
Epidemiology	Geographical distribution: from Japan to the Middle East and the Mediterranean basin
Ethnic origin	Prevalence in Berlin: high in Lebanese and Turks and low in Germans
HLA	HLA-B51 (B510101 subtype)
Genome-wide association studies	(i) MHC Class I region: HLA-B51 (B5101)
	(ii) Non-HLA regions: IL10 region and region between IL23R and IL12RB2
	(iii) Chromosome regions: 6q25-26, 12p12–13
Familial aggregation	(i) In patients with pediatric onset
	(ii) Autosomal-recessive Mendelian mode of inheritance in a pediatric subgroup
Twin concordance studies	High concordances in monozygotic twins
Gene polymorphism studies	Inconsistent and weak associations, further investigations are needed for definitive conclusions