Review Article
Genetics of Behçet's Disease
Table 1
Findings supporting the genetic background of Behçet’s disease.
| Studies | Findings/associations |
| Epidemiology | Geographical distribution: from Japan to the Middle East and the Mediterranean basin |
| Ethnic origin | Prevalence in Berlin: high in Lebanese and Turks and low in Germans |
| HLA | HLA-B51 (B510101 subtype) |
| Genome-wide association studies | (i) MHC Class I region: HLA-B51 (B5101) | (ii) Non-HLA regions: IL10 region and region between IL23R and IL12RB2 | (iii) Chromosome regions: 6q25-26, 12p12–13 |
| Familial aggregation | (i) In patients with pediatric onset | (ii) Autosomal-recessive Mendelian mode of inheritance in a pediatric subgroup |
| Twin concordance studies | High concordances in monozygotic twins |
| Gene polymorphism studies | Inconsistent and weak associations, further investigations are needed for definitive conclusions |
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