Prognostic Significance of N-Glycolyl GM3 Ganglioside Expression in Non-Small Cell Lung Carcinoma Patients: New Evidences

Figure 1

Microphotographs of formalin-fixed and paraffin-embedded NSCLC sections. Intense tissue reactivity of anti-EGFR (a), P3 (c), and 14F7 (e) Mabs without Neuraminidase (Clostridium perfringens) treatment. The expression of EGFR was not altered after enzymatic treatment (a), while the reactivity of P3 Mab was reduced but not completely eliminated (d) (brown color). Observe that the staining with 14F7 Mab was significantly removed after sialidase digestion (f) (brown color). Counterstaining with Mayer’s Hematoxylin (blue color). White bar = 100 μm.

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