Research Article
Predictive Response Value of Pre- and Postchemoradiotherapy Variables in Rectal Cancer: An Analysis of Histological Data
Table 5
Predictive value of clinical and pathological characteristics to Mandard response (univariate analysis).
| Variables | | Bad responders % (Mandard TRG 3–5) | Odds ratio | |
| Distance from anal verge | | | | | ≤6 cm | 86 | 58.0 | 1.00 | 0.017 | >6 cm | 81 | 39.5 | 2.11 (1.14–3.92) | | Mitosis number in resected specimen | | | | | ≤9.5 | 73 | 32.9 | 1.00 | <0.001 | ≥9.6 | 68 | 77.9 | 7.21 (3.40–15.32) | | Necrosis grade in resected specimen | | | | | Scarce | 27 | 77.8 | 10.36 (3.76–28.57) | <0.001 | Moderate | 38 | 92.1 | 34.53 (9.76–122.41) | <0.001 | Marked | 99 | 25.3 | 1.00 | <0.001 | CRM distance | | | | | ≥2 mm | 159 | 45.9 | 1.00 | 0.003 | <2 and >1 mm | 8 | 100 | 2.18 (1.84–2.58) | | ypT stage | | | | | 0-1 | 38 | 7.9 | 1.00 | <0.001 | 2–4 | 129 | 60.5 | 17.84 (5.21–61.09) | | ypN stage | | | | | 0 | 110 | 32.7 | 1.00 | | 1-2 | 57 | 78.9 | 7.71 (3.64–16.34) | <0.001 | Pathological stage | | | | | 0-I | 58 | 15.5 | 1.00 | <0.001 | II | 58 | 55.2 | 6.70 (2.78–16.14) | <0.001 | III | 51 | 78.4 | 19.80 (7.47–52.48) | <0.001 | T downstaging | | | | | Yes | 67 | 23.9 | 1.00 | <0.001 | No | 100 | 65.0 | 5.92 | | Pathological TNM downstaging | | | | | Yes | 96 | 34.4 | 1.00 | <0.001 | No | 70 | 67.1 | 3.90 | | Reduction of mitosis number | | | | | Yes | 83 | 41.0 | 1.00 | <0.001 | No | 52 | 73.1 | 3.91 (1.84–8.30) | | Differentiation grade in resected specimen | | | | | 0 + 1 | 52 | 15.4 | 1.00 | <0.001 | 2 + 3 | 115 | 63.5 | 9.56 | |
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