Research Article
Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-κB/p65 Signaling in Chronic Radiculitis Rats
Figure 1
Treatment with low-concentration O3 improved mechanical allodynia in chronic radiculitis rats. Implanted autologous nucleus pulposus (NP) led to ipsilateral radicular inflammation. There was no significant difference in paw withdrawal thresholds (PWTs) between groups to mechanical stimuli prior to operation. Ipsilateral PWTs in the control group and 10, 20, and 30 μg/mL O3 groups were significantly reduced on day 1 after NP implantation () compared to the PWT before the operation and to the sham group. After intrathecal O3 administration, the ipsilateral PWTs were significantly elevated in the 10, 20, and 30 μg/mL O3 groups () from day 2 to day 7 after NP implantation. Compared with the 10 μg/mL and 30 μg/mL O3 groups, the ipsilateral PWTs were significantly increased in the 20 μg/mL O3 group. The values are expressed as mean ± SEM. vs. sham group; vs. control group; vs. 10 μg/mL and 30 μg/mL O3 groups.