Low-Concentration Oxygen/Ozone Treatment Attenuated Radiculitis and Mechanical Allodynia via PDE2A-cAMP/cGMP-NF-κB/p65 Signaling in Chronic Radiculitis Rats

Figure 2

Low-concentration O₃ treatment reversed the overexpression of tumor necrosis factor- (TNF-) α, interleukin- (IL-) 1β, and IL-6 in chronic radiculitis rats. TNF-α, IL-1β, and IL-6 proteins were all significantly increased in the control group () on day 7 compared to the sham group. Compared to the control group, TNF-α, IL-1β, and IL-6 proteins were significantly decreased in the 10, 20, and 30 μg/mL O₃ groups (). These effects were most noticeable in the 20 μg/mL O₃ group () compared to those in the other O₃ groups. The values are expressed as mean ± SEM. vs. sham group; vs. control group; vs. 10 μg/mL and 30 μg/mL O₃ groups.