507029.fig.003
Figure 3: The effect of GLT-1 overexpression on the intracolonic (i-colo) TNBS-sensitized visceromotor response to graded colorectal distension were compared in female mice. In animals treated with 1-week vehicle and then intracolonic TNBS (100 μl, 7 mg/ml) (●), administered 1 week before the study, significant increased visceromotor response to colorectal distension (* 𝑃 < 0 . 0 5 ) was observed, compared to 1-week vehicle and intracolonic vehicle (○). One-week CTX treatment abolishes the enhanced visceromotor response to colorectal distension caused by intracolonic TNBS (▲). 𝑛 = 7-8/group. * 𝑃 < 0 . 0 1 compared to 1-week vehicle + intracolonic vehicle group.